Any genetic predisposition? Check our 500k application on healths predispositions

What are your health genetic predispositions?

 

The 500K application is coming from a database of 500.000 people in England. All those people in the database gave their DNA and many health informations about themselves.

It allows you to have a more detailed look at some of your health predispositions risks thanks to your DNA.

 

How does it work?

Your DNA will be compared with the other 500.000 DNA in the database. You could share some health predispositions risks or advantages with other people in the database: your DNA and some DNA in the database will be linked together thanks to similar DNA variants.

 

How it all started?

The initial goal is to create a database big enough to allow scientists to move forward with research.

“UK Biobank is a major national and international health resource, and a registered charity in its own right, with the aim of improving the prevention, diagnosis and treatment of a wide range of serious and life-threatening illnesses – including cancer, heart diseases, stroke, diabetes, arthritis, osteoporosis, eye disorders, depression and forms of dementia. UK Biobank recruited 500,000 people aged between 40-69 years in 2006-2010 from across the country to take part in this project. They have undergone measures, provided blood, urine and saliva samples for future analysis, detailed information about themselves and agreed to have their health followed. Over many years this will build into a powerful resource to help scientists discover why some people develop particular diseases and others do not.”

Read more

 

The first results available

With our application we recoup some of the results on many different potential health issues. Of course, please note that these results are just indicators of potential health risks or healths predispositions and for sure are not medical reports.

Our goal is to give access to potential health risks to people so that they know as quickly as possible if they would need to pay attention or to adjust activities, nutritions habits,… before even any health issue would arise.

Of course, check your doctor regularly for medical advices.

 

How are these results treated?

For each health risk we give you a result so that you know if your predisposition is highly above average, above average, average, below average, highly below average.

You will have an initial table with all the different health predispositions sorted by how they rank with the averages.

If you want to check those further, you can do it by looking at the different health categories.

 

What are the categories of those healths risks?

We grouped those in a few different categories: Diagnoses, Early life factors, Family history, Health and medical history, Lifestyle and environment, Medications, Operations, Physical measures, Psychosocial factors, Sex-Specific factors, Sociodemographics, Work Environment.

 

Analysis of more than 200 healths related factors

Each category has many different items. The goal of the categories was to regroup items with common characteristics.

Let’s check what are those different categories:

    • Diagnoses allows you to check any potential health risks predisposition. A few example of Diagnoses are: Anaemia, Angina, Ulcer, Shoulder issues,… there are more than 140 healths diagnoses in the database.
    • Early life factors contains data on questions related to early life exposures: area of birth, adoption, multiple birth, maternal smoking at birth, whether breastfed, handedness, and childhood body size.
    • Family history contains data on questions related to family size, sibling order, family medical history (of parents and siblings) and age of parents (age of death if died).
    • Health and medical history: contains information on past and current health, subdivided by medical conditions (including sets of questions related to some specific symptoms and/or conditions), cancer screening information, medications and operations… More than 250 fields…
    • Lifestyle and environment: contains information on lifestyle and personal exposures, subdivided into broad subject areas… As alcohol use, type of transport use, physical activity, smoking or not,…
    • Medications: contains data obtained through a verbal interview by a trained nurse on prescription medications and includes data on type and number of medications taken. If the participant indicated that they were taking any of the following classes of medications: blood pressure lowering, cholesterol lowering, hormone replacement therapy or oral contraceptive pills, then the interviewer was prompted to record the name of the medication.This category contains data on any regular treatments taken weekly, monthly, etc. It does not include short-term medications (such as a 1 week course of antibiotics) or prescribed medication that is not taken, or over-the-counter medications, vitamins and supplements. Doses and formulations were not recorded.
    • Operations: contains data on type of operation (grouped by body region, and presented in a tree structure), the number of operations, and date of each one.
    • Physical measures: contains information from physical measurements done at the Assessment Centre and is divided into subcategories based on the type of physical measure performed.
    • Psychosocial factors: contains information on psychosocial factors, subdivided into broad subject areas… as father or mother alive, irritability, death of a relative, risk taking,…
    • Sex-Specific factors: contains information in male and female subcategories.
    • Sociodemographics: contains information on sociodemographic factors, subdivided into broad subject areas… as college or university degree, retired or not, unemployed, transport to work,…
    • Work Environment: contains the result for the online Healthy Work questionnaire conducted from June through September 2015.

 

Have a look at the preview of the 500k app.

 

Are you depressed? Take the DNA depression test… coming soon at GenePlaza

More than 300 million people of all ages suffer from depression in the world, so about 4pc of the world population. Yes we are human… In a few weeks, GenePlaza will launch its new app to have a genetic test to measure your predisposition regarding depression.

Depression Key facts from the World Health Organization

  • a common mental disorder.
  • a leading cause of disability worldwide.
  • More women are affected than men.
  • At its worst, depression can lead to suicide.
  • There are effective psychological and pharmacological treatments.

More from the World Health Organization

 

What is Depression?

Depression (major depressive disorder) is a common and serious medical illness that negatively affects how you feel, the way you think and how you act. Fortunately, it is also treatable. Depression causes feelings of sadness and/or a loss of interest in activities once enjoyed. It can lead to a variety of emotional and physical problems and can decrease a person’s ability to function at work and at home. More on Psychiatry.org

Major symptoms

  • Feelings of guilt, worthlessness, or helplessness
  • Decreased energy or fatigue
  • Moving or talking more slowly
  • Feeling sad or having a depressed mood
  • Loss of interest or pleasure in activities once enjoyed
  • Changes in appetite — weight loss or gain unrelated to dieting
  • Trouble sleeping or sleeping too much
  • Feeling restless or having trouble sitting still
  • Difficulty concentrating, remembering, thinking or making decisions
  • Early-morning awakening, or oversleeping
  • Loss of energy or increased fatigue
  • Increase in purposeless physical activity (e.g., hand-wringing or pacing) or slowed movements and speech (actions observable by others)
  • Thoughts of death or suicide, or suicide attempts
  • Persistent sad, anxious, or “empty” mood
  • Feelings of hopelessness, or pessimism
  • IrritabilityFeeling restless or having trouble sitting stillAppetite and/or weight changes
  • Aches or pains, headaches, cramps, or digestive problems without a clear physical cause and/or that do not ease even with treatment

Risk factors

It is one of the most common mental disorders in the world. Current research suggests that depression is caused by a combination of genetic, biological, environmental, and psychological factors.

  • Personal or family history
  • Major life changes, trauma, or stress
  • Certain physical illnesses and medications
  • Biochemistry: Differences in certain chemicals in the brain may contribute to symptoms of depression.
  • Genetics: Depression can run in families. For example, if one identical twin has depression, the other has a 70 percent chance of having the illness sometime in life.
  • Personality: People with low self-esteem, who are easily overwhelmed by stress, or who are generally pessimistic appear to be more likely to experience depression.
  • Environmental factors: Continuous exposure to violence, neglect, abuse or poverty may make some people more vulnerable to depression.

 

More on Psychiatry.org

Insights from the world health organisation

Depression is different from usual mood fluctuations and short-lived emotional responses to challenges in everyday life. Especially when long-lasting and with moderate or severe intensity, depression may become a serious health condition. It can cause the affected person to suffer greatly and function poorly at work, at school and in the family. At its worst, depression can lead to suicide. Close to 800 000 people die due to suicide every year. Suicide is the second leading cause of death in 15-29-year-olds.

Although there are known, effective treatments for depression, fewer than half of those affected in the world (in many countries, fewer than 10%) receive such treatments. Barriers to effective care include a lack of resources, lack of trained health-care providers, and social stigma associated with mental disorders. Another barrier to effective care is inaccurate assessment.

 

Depression statistics for some countries in the world (alphabetical ranking)

  • Belgium: 14%
  • France: 21%
  • Germany: 10%
  • Israel: 10%
  • Italy: 10%
  • Japan: 6%
  • New Zealand: 18%
  • Spain: 11%
  • United States: 19%

Here is the full study coming from BMC Medecine.

Treatment and Therapies

Mainly medications and psychotherapies, check the site of the National Institute of Mental Health.

Are you depressed?

Let’s have a look at a few tests:

Coming soon… GenePlaza will implement the genetic based research to help you to understand your genetic predisposition to depression. 

It will tell you if you have a higher risk or lower risk to be depressed according to your genes. We all know that we have health predispositions due to our ancestors as written above:

Genetics are one of the main risk factors for depression: Depression can run in families. For example, if one identical twin has depression, the other has a 70 percent chance of having the illness sometime in life.

 

Do you want to take this test?

At GenePlaza, we help people to get to know themselves better thanks to our App Store.